The GHK-Cu peptide, or glycyl-L-histidyl-L-lysine copper complex, is a tripeptide with the amino acid sequence Gly-His-Lys, bound to a copper(II) ion. Its chemical formula is C14H24N6O4Cu, with a molecular weight of approximately 403.9 g/mol. The copper ion (Cu²⁺) coordinates primarily with the nitrogen atoms of the histidine imidazole ring, the glycine amino group, and the peptide backbone, often forming a square planar or distorted octahedral complex.
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