GLP-3 is a 39-amino acid peptide with triple agonist activity at the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Its chemical structure is derived from a GIP peptide backbone with specific modifications to enhance stability and receptor selectivity. The peptide sequence is:
 
YA¹QGTFTSDYSIL²LDKK⁴AQA¹AFIEYLLEGGPSSGAPPPS³
 
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