Melanotan II is a synthetic cyclic heptapeptide. The structure features a lactam bridge between the aspartic acid (Asp) and lysine (Lys) side chains, forming a cyclic conformation. It is acetylated at the N-terminus (Ac) and amidated at the C-terminus (NH2), with norleucine (Nle) as a non-natural amino acid and D-phenylalanine (D-Phe) for enhanced stability and activity. This structure contributes to its melanocortin receptor-binding properties.
MT-2 amino acid sequence is: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
 
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